I believe that both term are misused >95% of the time they appear.
A "hybrid" is a cross between two known, defined types of anything. A marble that is a hybrid should have clear qualities of two known marble types that we can actually name. People have become lazy with the term to mean that it has something a little (or a lot) off from a know type. A blob of an unintended color isn't a "hybrid", but using the word "hybrid" seems to lean towards inferring that it is either more rare or desirable (usually with not much appreciation of marble-making).
A marble "run" could last as long as the tank did not require rebuilding. A tank and the associated machinery were made to last as long as reasonably possible within the limits of cost. Keep in mind that marble production wasn't a random, experimental process. Manufacturers had a catalog of designs and salesmen that sold to and took specific orders from retailers. Retailers ordered specifically what they wanted and knew sold well - not "Give me whatever you want". Manufacturer Salesman's cases showed what was available and in what sizes, as did their advertisements. Akro could produce yellow and blue corkscrews for years and years - and did. Akro (for example) shipped three full train boxcars at least twice each week - and that doesn't count truck transport.
Use of the term "Same run" (I see it more and more) to describe machine mades shows a lack of understanding of vintage marble manufacturing. Whatever design it is was most likely produced for at least a year - probably longer. And they did their best to ensure consistency to the basic design and color, again within cost constraints. Marbles that didn't meet consistency or quality requirements went to the dump sites(and they discarded a LOT of marbles). So how could anyone know that two marbles were made in which week or month? Especially when they were supposed to look the same. 'Mike' running machines #1-3 wasn't given leeway to make whatever he wanted that struck his whimsy. This was a business filling specific orders from retailers and wholesalers. For years. No-one who uses the word "run" could tell you how they know when that "run" was active
"End of run" is a bad corruption of "End of cane" from handmade marbles. It doesn't describe anything that anyone can actually name. Hence it isn't helpful or descriptive more than "hybrid".